Metæ joined in and replied with this 11 years ago, 14 minutes later[^][v]#549,762
Alcohol's not a drug, its a drink. Thanks.
(Edited 30 seconds later.)
Anonymous A (OP) replied with this 11 years ago, 9 minutes later, 23 minutes after the original post[^][v]#549,763
@previous (Metæ)
You've obviously never been to rehab. They say that alcohol is a drug. Technically you could mix codeine in cola and call it a drink. And what of caffeine?
Anonymous A (OP) double-posted this 11 years ago, 2 minutes later, 25 minutes after the original post[^][v]#549,764
Lemon Drop !CITRUS3QCY joined in and replied with this 11 years ago, 12 minutes later, 38 minutes after the original post[^][v]#549,766
I just drink.
Anonymous D joined in and replied with this 11 years ago, 17 minutes later, 56 minutes after the original post[^][v]#549,767
Write in; not sure
Killer Lettuce !!iNo3FkiZx joined in and replied with this 11 years ago, 14 minutes later, 1 hour after the original post[^][v]#549,771
> research chemicals
That's very vague... And dangerous sounding.
Anonymous F joined in and replied with this 11 years ago, 17 minutes later, 1 hour after the original post[^][v]#549,773
Del and stim and weed
Lemon Drop !CITRUS3QCY replied with this 11 years ago, 2 minutes later, 1 hour after the original post[^][v]#549,774
@549,771 (Killer Lettuce !!iNo3FkiZx)
What sort of things would qualify under this category?
Anonymous A (OP) replied with this 11 years ago, 45 minutes later, 2 hours after the original post[^][v]#549,777
@549,771 (Killer Lettuce !!iNo3FkiZx) @previous (Lemon Drop !CITRUS3QCY)
Spice, ethylphenidate (yes, I know the cat does them), and plant matter what they done did even spray the chemicals on.
The Owl !KThEOwLwbU joined in and replied with this 11 years ago, 1 hour later, 3 hours after the original post[^][v]#549,780
Green (OP) replied with this 11 years ago, 13 minutes later, 7 hours after the original post[^][v]#549,842
@549,836 (TTEH !FFSTTEHV7.)
opiates>psychedelics>alcohol for me. Alcohol is the most addictive though.
Broseph !!fxnDb+Ve4 replied with this 11 years ago, 4 minutes later, 7 hours after the original post[^][v]#549,843
I've never understood the appeal of opiates. I look at how addictive they are and the harm they do and how they make people feel and I just don't get it. But that's just me. I'm all about uppers, not downers.
Green (OP) replied with this 11 years ago, 39 minutes later, 8 hours after the original post[^][v]#549,845
@previous (Broseph !!fxnDb+Ve4)
It's the best drug to use if you feel rough.
hamfist !t5TYQ9eJPs joined in and replied with this 11 years ago, 45 minutes later, 8 hours after the original post[^][v]#549,853
@549,843 (Broseph !!fxnDb+Ve4)
ive done some hydrocodone a few times and never got addicted, but the high isn't especially great. i'd rather do amphetamine again
Anonymous Q joined in and replied with this 11 years ago, 32 minutes later, 9 hours after the original post[^][v]#549,873
i found a ecstasy pill once and I ate it in bed
kook !!mCVqftDha joined in and replied with this 11 years ago, 6 minutes later, 9 hours after the original post[^][v]#549,875
I like weed, muscle relaxers, pain pills, things like Ativan and Valium, and Ambien.
Anonymous S joined in and replied with this 11 years ago, 13 minutes later, 9 hours after the original post[^][v]#549,879
> I like weed, muscle relaxers, pain pills, things like Ativan and Valium, and Ambien.
how is ambien
kook !!mCVqftDha replied with this 11 years ago, 5 minutes later, 9 hours after the original post[^][v]#549,885
@previous (S)
I only use it for sleep, but its very good at that. Unlike some, it doesnt make me sleepwalk or give me vivid nightmares.
Catherine !TGirlYJKXM joined in and replied with this 11 years ago, 12 minutes later, 10 hours after the original post[^][v]#549,894
Write In: None
Green (OP) replied with this 11 years ago, 6 minutes later, 10 hours after the original post[^][v]#549,896
@previous (Catherine !TGirlYJKXM)
You haven't tried any. I used to be the same way as you, saying that drugs were bad, you should try some. Do you drink coffee, tea etc?
(Edited 5 minutes later.)
Anonymous S replied with this 11 years ago, 21 minutes later, 10 hours after the original post[^][v]#549,901
> I only use it for sleep, but its very good at that. Unlike some, it doesnt make me sleepwalk or give me vivid nightmares.
ive heard the total opposite, everything so far has just been about people waking up and like, are outside of their homes or like cooking in their sleep and stuff, it sounds terrifying.
Meowth joined in and replied with this 11 years ago, 19 minutes later, 10 hours after the original post[^][v]#549,904
@OP
This is more of like a checklist of what I love the more than just weed.. I can't even choose what I'd prefer, although opiates for lyf. I can't choose just opiates over psychedelics or dissociatives, though. DXM alone is both a dissociative and psychedelic. Not to mention, DXM is also used for opiate addiction treatment.
Anonymous S replied with this 11 years ago, 3 minutes later, 11 hours after the original post[^][v]#549,906
(PMID: 19806811) Development of morphine induced tolerance and withdrawal symptoms is attenuated by lamotrigine and magnesium sulfate in mice
From these results it is concluded that lamotrigine and magnesium sulfate alone or in combination could prevent the development of morphine tolerance and withdrawal symptoms. Glutamate release inhibitory effect of lamotrigine and its possible mechanism and property of magnesium, blocking the N-Methyl-D-Aspartate (NMDA) receptor calcium channel, is probably its mechanism on preventing morphine induced tolerance and dependence.
(PMID: 19764437) Anti-opioid action of glutamate-NMDA receptor systems underlying morphine analgesic tolerance
The mechanisms underlying opioid tolerance are not fully understood, but appear to be comprised of two types of plasticity or counter-adaptation, at the cellular level and through neuronal circuits. Current studies mostly emphasize the cellular adaptation mechanisms, which include altered gene expression and receptor desensitization due to phosphorylation and endocytosis. However, the mechanisms underlying opioid tolerance and dependence are not always explained by cellular adaptation mechanisms alone. This review focuses on the plasticity in neuronal circuits achieved through an enhancement of so-called anti-opioid glutamate/NMDA receptor synaptic activities.
(PMID: 18819620) Evaluation the effects of dextromethorphan and midazolam on morphine induced tolerance and dependence in mice.
From these results it may concluded that Dextromethorphan and midazolam alone or in combination could prevent the development of morphine induced tolerance and dependence. These effects can be related to the N-Methyl-D-Aspartate (NMDA) receptor antagonist behavior of Dextromethorphan and GABA-receptor agonist property of midazolam.
(PMID: 18177675) The glycine site-specific NMDA antagonist (+)-HA966 enhances the effect of morphine and reverses morphine tolerance via a spinal mechanism
Using the C-fibre reflex as a nociceptive response elicited by a wide range of stimulus intensities in the rat, we recently reported that a single treatment with (+)-HA966, a glycine site-specific NMDA receptor antagonist: (1) potentiates morphine antinociception; and (2) reverses an established morphine tolerance.
(PMID: 17994223) NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats
CONCLUSIONS: The results, together with previous research, suggest that NMDA receptors are broadly involved in opiate-induced plasticity, including the development of opiate tolerance and sensitization.
Anonymous V joined in and replied with this 11 years ago, 14 minutes later, 11 hours after the original post[^][v]#549,917
kook !!mCVqftDha replied with this 11 years ago, 11 minutes later, 11 hours after the original post[^][v]#549,919
Though the only time that I've ever had sleep paralysis,I was on Ambien.
Broseph !!fxnDb+Ve4 replied with this 11 years ago, 1 hour later, 13 hours after the original post[^][v]#549,924
@previous (kook !!mCVqftDha)
Remember the time I took ambien and logged my experience here? I read the thread the next morning and didn't remember typing it.
Anonymous S replied with this 11 years ago, 2 minutes later, 13 hours after the original post[^][v]#549,925
>(PMID: 19806811) Development of morphine induced tolerance and withdrawal symptoms is attenuated by lamotrigine and magnesium sulfate in mice > From these results it is concluded that lamotrigine and magnesium sulfate alone or in combination could prevent the development of morphine tolerance and withdrawal symptoms. Glutamate release inhibitory effect of lamotrigine and its possible mechanism and property of magnesium, blocking the N-Methyl-D-Aspartate (NMDA) receptor calcium channel, is probably its mechanism on preventing morphine induced tolerance and dependence. > >(PMID: 19764437) Anti-opioid action of glutamate-NMDA receptor systems underlying morphine analgesic tolerance > The mechanisms underlying opioid tolerance are not fully understood, but appear to be comprised of two types of plasticity or counter-adaptation, at the cellular level and through neuronal circuits. Current studies mostly emphasize the cellular adaptation mechanisms, which include altered gene expression and receptor desensitization due to phosphorylation and endocytosis. However, the mechanisms underlying opioid tolerance and dependence are not always explained by cellular adaptation mechanisms alone. This review focuses on the plasticity in neuronal circuits achieved through an enhancement of so-called anti-opioid glutamate/NMDA receptor synaptic activities. > >(PMID: 18819620) Evaluation the effects of dextromethorphan and midazolam on morphine induced tolerance and dependence in mice. > From these results it may concluded that Dextromethorphan and midazolam alone or in combination could prevent the development of morphine induced tolerance and dependence. These effects can be related to the N-Methyl-D-Aspartate (NMDA) receptor antagonist behavior of Dextromethorphan and GABA-receptor agonist property of midazolam. > >(PMID: 18177675) The glycine site-specific NMDA antagonist (+)-HA966 enhances the effect of morphine and reverses morphine tolerance via a spinal mechanism > Using the C-fibre reflex as a nociceptive response elicited by a wide range of stimulus intensities in the rat, we recently reported that a single treatment with (+)-HA966, a glycine site-specific NMDA receptor antagonist: (1) potentiates morphine antinociception; and (2) reverses an established morphine tolerance. > >(PMID: 17994223) NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats > CONCLUSIONS: The results, together with previous research, suggest that NMDA receptors are broadly involved in opiate-induced plasticity, including the development of opiate tolerance and sensitization.
great that doesn't tell me anything, all of those talk about the receptors and tests in rats, none of them say anything about treating heroin addiction with dxm only that its a possibility that it could be
kook !!mCVqftDha replied with this 11 years ago, 3 minutes later, 13 hours after the original post[^][v]#549,926
@549,924 (Broseph !!fxnDb+Ve4)
I dont remember! Do you have a link to that?
Broseph !!fxnDb+Ve4 replied with this 11 years ago, 2 hours later, 15 hours after the original post[^][v]#549,959
@previous (kook !!mCVqftDha)
I was just trying to find it. I could not. Apparently I was awake but dreaming and typing out the dream. I asked the board if I was in a battle.
hamfist !t5TYQ9eJPs replied with this 11 years ago, 3 days later, 4 days after the original post[^][v]#551,425
i just took some vicodin gonna get turnt as fuck
Anonymous W joined in and replied with this 11 years ago, 12 minutes later, 4 days after the original post[^][v]#551,429
vaporize weed erryday
Green (OP) replied with this 11 years ago, 4 hours later, 4 days after the original post[^][v]#551,455